Can You Ever
Quit TRT?

Can You Ever Quit TRT? Exploring the Long-Term Effects of TRT

Can you ever quit TRT? Learn more about the effects of quitting TRT and if it’s the right option for you.

Table of Contents

Testosterone Replacement Therapy: Overview

Testosterone replacement therapy (TRT) is a medical treatment that aims to supplement the body with testosterone. Testosterone is a hormone essential for the development of male characteristics and the maintenance of health and well-being. However, it is important to understand the long-term effects of TRT and whether or not it is a life-long treatment. Is TRT right for you? Can you ever quit TRT?

In this article, we will explore what TRT is, how long people take it, the consequences of quitting TRT cold turkey over time, how TRT can increase quality of life, and why people might want to quit TRT.
Can you Ever Quit TRT?

What is Testosterone Replacement Therapy (TRT)?

TRT is a common treatment for men who suffer from hypogonadism, a condition in which the body does not produce enough testosterone. TRT has been found to help alleviate symptoms associated with low T levels such as fatigue, depression, low libido, and loss of muscle mass.1

How Long Do People Take TRT?

Can you ever quit TRT, or is it a temporary treatment? The duration of TRT treatment varies depending on the individual. Generally, TRT is a long-term treatment that can last for years. The length of treatment is influenced by several factors, including the age of the individual, the severity of the condition, and the goals of treatment.

How Long Does it Take for TRT to Show Effects?

Below is a comprehensive list of the timeframe TRT takes to show effects for each condition:2
  • Sexual interest: effects appear after 3 weeks, plateauing at 6 weeks, with no further increments expected beyond.
  • Erections/Ejaculations: changes may require up to 6 months.
  • Quality of life: effects manifest within 3–4 weeks, but maximum benefits take longer.
  • Depressive mood: effects become detectable after 3–6 weeks with a maximum after 18–30 weeks.
  • Erythropoiesis: effects are evident at 3 months, peaking at 9–12 months.
  • Prostate-specific antigen and volume: rise marginally, plateauing at 12 months.
  • Lipids: effects appear after 4 weeks, maximal after 6–12 months.
  • Insulin sensitivity: may improve within a few days, but effects on glycemic control become evident only after 3–12 months.
  • Fat mass, lean body mass, and muscle strength: changes occur within 12–16 weeks, stabilize at 6–12 months, but can marginally continue over years.
  • Inflammation: effects occur within 3–12 weeks.
  • Bone: effects are detectable already after 6 months while continuing at least for 3 years.

Is TRT a Life-Long Treatment?

Can you ever quit TRT? Whether or not TRT is a life-long treatment depends on the individual. For some men with hypogonadism, TRT is a life-long treatment. However, for others, TRT may only be needed for a few years. Long-term use of TRT can have both positive and negative effects on the body.

Some studies have found that long-term use of TRT can help to improve bone density and reduce the risk of cardiovascular disease. However, long-term use of TRT has also been associated with an increased risk of infertility, sleep apnea, cardiovascular events, enlarged chest, and more.

Can You Ever Quit TRT? What Happens if You Quit TRT Cold Turkey?

Can you ever quit TRT cold turkey? Quitting TRT cold turkey can have significant impacts on the body. When TRT treatment is abruptly stopped, the body’s natural production of testosterone may be suppressed. Studies suggest that interrupting TRT can result in a worsening of symptoms and that hypogonadism may require lifelong treatment.3

Symptoms of Ceasing Treatment

Quitting TRT cold turkey can result in any or all of the following symptoms:
  • Total testosterone levels may drop to hypogonadal levels
  • Obesity parameters (weight, BMI, and waist circumference) may worsen
  • Worsening of aging male symptoms
  • Impact on International Prostate Symptoms Scores
  • Residual voiding volume and bladder wall thickness may worsen
  • Reduced erectile function
  • Prostate-specific antigen (PSA) levels may increase
  • Prostate volume may increase
  • C-reactive protein (CRP) levels may remain unchanged

Withdrawal Symptoms

Stopping your testosterone can result in withdrawal symptoms, including:4
  • Mood changes
  • Insomnia 
  • Lack of clarity
  • Appetite loss
  • Muscle loss
  • Anxiety and depression

Can You Ever Quit TRT? What Happens If You Quit TRT Over Time?

One of the most common questions about this treatment is can you ever quit TRT? Yes, but you should not without first consulting with a trusted physician. Your doctor will decide the best course of action for quitting TRT after considering your dose, your symptoms, your age, and other factors.

Can You Ever Quit TRT Safely?

Gradually stopping TRT, also known as tapering, is a safer way to quit. Tapering allows the body to adjust to the changes in testosterone levels, reducing the risk of withdrawal symptoms. However, tapering off TRT can still have consequences on the body. Some men may experience symptoms of hypogonadism, such as fatigue, depression, and low libido.
The longer you’ve been on TRT, the longer it takes for your body to return to normal. It can take weeks to months to resolve the symptoms of ceasing TRT.

Why Would People Want to Quit TRT

When used appropriately, TRT can significantly improve quality of life for individuals with low testosterone levels. However, there are several reasons why someone may ask, “can you ever quit TRT?”

Personal Choice

Some individuals may decide to quit TRT simply because they no longer wish to continue treatment. This may be due to a change in lifestyle or a desire to try alternative treatments.

Side Effects

While TRT can provide significant benefits, it can also come with side effects. Common side effects of TRT include acne, breast enlargement, mood swings, and sleep apnea. Individuals who experience these side effects may choose to quit to alleviate their symptoms.


TRT can be expensive, and some people may choose to quit treatment due to financial constraints.

Medical Reasons

There may be medical reasons why a person would need to cease treatment For example, if a man is diagnosed with prostate cancer or breast cancer while on TRT, he may need to stop treatment.

Fertility Concerns

TRT can have an impact on fertility by decreasing sperm production. If an individual is concerned about their fertility, they may choose to quit or consider alternative treatments.

Improved Quality of Life

Some people may start to feel better and consider quitting the treatment. Unfortunately, once you stop taking TRT, you might feel the same way you felt before taking the testosterone doses.
Can you Ever Quit TRT?

Immortal Male and Quitting TRT

At Immortal Male, we understand the challenges that come with low testosterone levels. Our online clinic offers safe and effective solutions to help maintain healthy sexual function and address other issues related to low T levels.
If you’re asking the question, “can you ever quit TRT?”, we can help guide you through the process and determine if it is the best option for you. We encourage you to ask us any questions and contact us to learn more about our services. Let us help you achieve optimal health and vitality.


Can you ever quit TRT? Quitting cold turkey can have consequences on the body, including symptoms of TRT withdrawal while tapering off TRT can still lead to symptoms of hypogonadism. TRT has been found to improve the quality of life for some individuals, but long-term use of TRT is associated with potential risks and side effects.

If you are considering quitting TRT, it is important to speak with your healthcare provider to discuss the potential risks and benefits of tapering off or discontinuing treatment.

Journal of Clinical Endocrinology and Metabolism

Stephanie T. Page, John K. Amory, F. DuBois Bowman, Bradley D. Anawalt, Alvin M. Matsumoto, William J. Bremner, J. Lisa Tenover, Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T, The Journal of Clinical Endocrinology & Metabolism, Volume 90, Issue 3, 1 March 2005, Pages 1502–1510,