Does TRT
Reduce Anxiety?

Does TRT Reduce Anxiety?

Get answers to questions like “what is testosterone replacement therapy?” and “does TRT reduce anxiety?”

Table of Contents

Does TRT Reduce Anxiety?

Testosterone is the primary male sex hormone. It is responsible for stimulating the growth and development of male sex organs. It’s also important for maintaining muscle mass, bone density, and a healthy libido. How does TRT reduce anxiety? 

Anxiety is a common mental disorder characterized by feelings of worry, fear, and uneasiness. The impact of anxiety on an individual’s quality of life can be significant. Those struggling with anxiety may experience difficulties in their personal and professional relationships, reduced productivity at work, and diminished well-being.
Does TRT reduce anxiety?

Connection between Testosterone Levels and Anxiety

Studies have found that there is a connection between testosterone levels and anxiety. Low testosterone has been associated with increased anxiety, while higher levels of the hormone can reduce stress and anxiety.1

Testosterone replacement therapy (TRT) has been used to treat men with low levels of the hormone. TRT is a form of hormone therapy where testosterone levels are boosted to the normal range.
So, does TRT reduce anxiety? In short, TRT is posited to reduce the risk of depression and anxiety.

How TRT Works to Reduce Anxiety

How does TRT reduce anxiety? The exact mechanisms by which TRT reduces anxiety are not yet fully understood. Several theories have been proposed based on existing research. Some potential mechanisms are detailed below.

Neurotransmitter Modulation

Testosterone is known to influence the levels of various neurotransmitters in the brain. These include serotonin, dopamine, and GABA. These neurotransmitters play essential roles in mood regulation and anxiety management. TRT may help balance these neurotransmitter levels, thereby reducing anxiety symptoms.2

Brain-Derived Neurotrophic Factor (BDNF)

Testosterone has been shown to increase the expression of BDNF, a protein that promotes the growth and survival of nerve cells in the brain. Higher BDNF levels have been associated with reduced anxiety and improved mood.3


Testosterone may promote the growth of new neurons in the hippocampus. This is a brain region involved in mood regulation and stress response. This process, known as neurogenesis, could help reduce anxiety symptoms.4

Effects of TRT on Mood, Cognition, and Anxiety Symptoms

Several studies have reported positive effects of TRT. Some of the observed benefits include:

  • Improved mood: TRT has been shown to improve self-reported measures of mood and well-being.5
  • Cognitive enhancement: TRT has been associated with improved memory, concentration, and cognitive performance.
  • Reduced anxiety symptoms: Studies have reported that testosterone supplementation can reduce general feelings of anxiety and stress.
  • Reduced fatigue: TRT may reduce feelings of tiredness and exhaustion, which are associated with anxiety disorders.

When and How Does TRT Reduce Anxiety?

Although TRT has been associated with reduced anxiety symptoms, it is important to note that the therapy is not a cure-all. It is not suitable for everyone. It should only be used under the guidance of a physician.
Does TRT reduce anxiety? TRT may be most effective in reducing anxiety for those with low testosterone levels, as this is the primary hormonal abnormality that TRT seeks to address. It may also benefit those with other hormonal imbalances or underlying health conditions that can cause anxiety.

The Role of Individual Factors

Several individual factors can influence the effectiveness of TRT in reducing anxiety, including:

  • Age: Older individuals may respond better to TRT than younger ones, as testosterone levels tend to decline with age.
  • Weight: Those who are overweight or obese may respond better to TRT, as higher body fat can reduce testosterone levels.
  • Genetic background: Certain genetic variations may influence how an individual responds to testosterone supplementation.
  • Underlying health conditions: Certain underlying health conditions, such as diabetes or high cholesterol, can influence the effectiveness of TRT.


When does TRT reduce anxiety? The optimal duration and dosage of TRT for anxiety reduction may vary based on individual factors and the severity of symptoms. A healthcare professional will tailor the treatment plan to each patient’s unique needs, monitoring their progress and making adjustments as necessary.

When to Expect Results

In general, patients undergoing TRT may start to experience improvements in mood and anxiety symptoms within a few weeks of initiating treatment. However, it may take several months to achieve the full benefits of the therapy. The duration of treatment will depend on the patient’s response and any potential side effects.
As for dosage, healthcare providers will typically start with a conservative approach, increasing the dose as needed. The specific dosage and administration method (e.g., injections, patches, or gels) will depend on the factors above.

Potential Risks and Side Effects of TRT

Like any medication, TRT carries certain risks and side effects that should be considered before beginning treatment. These may include:

  • Acne and oily skin: An increase in testosterone levels can lead to increased sebum production. This can result in acne and oily skin.
  • Sleep disturbances: TRT may contribute to sleep apnea, a condition characterized by temporary pauses in breathing during sleep.
  • Testicular shrinkage: TRT can cause testicular shrinkage and reduced sperm production in men. This could affect fertility.
  • Increased red blood cell count: TRT may lead to a higher red blood cell count. This increases the risk of blood clots and other cardiovascular complications.
  • Mood swings and irritability: Although TRT can improve mood and reduce anxiety for some individuals, others may experience mood swings or increased irritability. This is mostly due to an imbalance of hormones.
  • Increased risk of certain conditions: TRT may increase the risk of developing prostate cancer, benign prostatic hyperplasia, or worsening existing prostate conditions in men.

Weighing the Benefits and Risks of Anxiety Reduction

Does TRT reduce anxiety enough to be worth the risk? Before initiating TRT, healthcare providers will typically perform an initial assessment to determine the patient’s suitability for the therapy. This usually involves a blood test to measure testosterone levels and a physical exam.

If you are deemed suitable for TRT, healthcare providers can discuss the potential benefits and risks of treatment with them. You should discuss any concerns or questions you may have before proceeding.

Does TRT Reduce Anxiety?

TRT at Immortal Male

If you find yourself asking questions like “does TRT reduce anxiety,” Immortal Male has the answers. At Immortal Male, we understand the complex relationship between testosterone levels and anxiety.  Our team members are well-versed in the latest research and developments in the field of testosterone replacement therapy. We are committed to providing the highest standard of care to our patients.

What We Offer

Our process is designed to make it easy and convenient for our patients to access the care they need. We offer telehealth consultations so you can receive personalized support and guidance from your home.

We also understand the importance of monitoring, and our team will work with you to ensure that your treatment is effective and safe.

Contact Immortal Male Today

If you are interested in getting answers to questions like “does TRT reduce anxiety,” reach out to Immortal Male today for more information about testosterone replacement therapy.

Journal of Clinical Endocrinology and Metabolism

Stephanie T. Page, John K. Amory, F. DuBois Bowman, Bradley D. Anawalt, Alvin M. Matsumoto, William J. Bremner, J. Lisa Tenover, Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T, The Journal of Clinical Endocrinology & Metabolism, Volume 90, Issue 3, 1 March 2005, Pages 1502–1510,