Is it Safe to Try

Is it Safe to Try TRT?

Is it safe to try TRT? Learn about the benefits, guidelines, and precautions to consider before starting testosterone replacement therapy.

Table of Contents

What is Testosterone?

Testosterone is a vital hormone primarily produced in men’s testicles. It is responsible for various functions, such as maintaining muscle mass and bone density and regulating sexual function. TRT involves supplementing the body with synthetic testosterone to restore hormone levels to a normal range.


Why is TRT Used?

As men age, their testosterone levels naturally decline. This can lead to several symptoms that negatively impact their quality of life. Common issues related to low testosterone levels include fatigue, mood swings, decreased libido, and difficulty building muscle mass.

TRT is used to alleviate these symptoms by increasing testosterone levels. This helps men feel more energized, focused, and confident, making it potentially safe to try TRT for those experiencing low testosterone levels.

Who Can Benefit From TRT?

TRT may be beneficial for men experiencing symptoms associated with low testosterone levels. These symptoms can occur due to aging, medical conditions such as hypogonadism, or as a result of certain treatments like chemotherapy.

Is it safe to try TRT? For those who are good candidates, it may be safe to try TRT under the guidance of a healthcare provider.

Types of Testosterone Replacement Therapy

Each type has its unique advantages and potential drawbacks. This can impact the overall safety and effectiveness of the treatment. Below are the five primary types of TRT.

Gels and Creams

Is it safe to try TRT topically? When used as directed, topical gels and creams can be a safe method for many men. These are applied directly to the skin, allowing the testosterone to be absorbed into the bloodstream. They are convenient and easy to use but require daily application. 

It’s important to avoid skin-to-skin contact with others for a few hours after applying the gel or cream, as the testosterone can be transferred to them.


Intramuscular injections involve injecting testosterone directly into the muscles. These are usually given every two to four weeks.  For individuals without contraindications, injections can be a safe method that provides consistent hormone release.


Subcutaneous pellets are small, slow-release pellets that are implanted under the skin, usually in the hip or buttock area. They release testosterone steadily over several months. This reduces the need for frequent treatments.

However, the procedure requires a minor surgical intervention, and there’s a risk of pellet extrusion or infection at the implant site.


Transdermal patches are worn on the skin and deliver testosterone directly into the bloodstream. They are convenient and offer a consistent release of the hormone. However, some users may experience skin irritation at the application site, and the patch must be replaced daily.

Oral Medications

Is it safe to try TRT orally? Oral medications are taken by mouth and offer a non-invasive method of TRT. However, they may be less effective than other methods. The liver metabolizes testosterone, which can lead to a lower overall absorption rate.

Additionally, long-term use of oral testosterone may increase the risk of liver toxicity.

Potential Benefits and Positive Side Effects of TRT

Many men have experienced significant improvements in their overall well-being and health due to TRT.1

Below are the major benefits and positive side effects associated with TRT.

Improved Mood and Cognitive Function

Low testosterone levels can lead to mood swings, irritability, and even depression. TRT can help improve mood and emotional well-being by stabilizing testosterone levels. Additionally, some studies suggest that TRT may enhance cognitive function, including memory and concentration.

Increased Muscle Mass and Bone Density

Testosterone plays a crucial role in maintaining muscle mass and bone density. By restoring testosterone levels, TRT can promote increased muscle mass and prevent the loss of bone density. This may reduce the risk of osteoporosis and fractures in older men.

Enhanced Sexual Function

Low testosterone levels can contribute to decreased libido and erectile dysfunction. TRT can help improve sexual function and satisfaction by increasing testosterone levels. This leads to a healthier and more fulfilling sex life.

Reduced Risk of Anemia and Cardiovascular Disease

Testosterone deficiency has been linked to an increased risk of anemia and cardiovascular disease. TRT can help reduce these risks by improving red blood cell production and promoting better overall heart health.

Patient Evaluation and Monitoring

It’s essential to start with a thorough baseline assessment. This evaluation helps your healthcare provider determine if TRT is right for you. The initial assessment includes a detailed medical history, physical examination, and laboratory tests.

The medical history focuses on your symptoms, lifestyle factors, and any pre-existing medical conditions. Blood tests are crucial in measuring your testosterone levels. Your healthcare provider will typically check for both total testosterone and free testosterone levels.

These tests are usually performed in the morning when testosterone levels are at their peak.  

Contraindications and Precautions

TRT may not be suitable for everyone. Understanding these contraindications and precautions will help you determine if it’s safe to try TRT in your specific situation.

Some factors that might make TRT unsuitable for you include:

  • A history of prostate or breast cancer
  • Severe sleep apnea
  • Uncontrolled heart failure or heart disease
  • A high red blood cell count

Your healthcare provider will carefully consider these factors before recommending TRT to ensure your safety.

Ongoing Monitoring and Follow-Up

With proper monitoring and follow-up, it is more likely to be safe to try TRT, as any side effects or complications can be promptly addressed. Your testosterone levels, prostate health, and red blood cell count are among the primary concerns during follow-up appointments.

If you experience any side effects or complications, your healthcare provider may adjust your TRT dosage or recommend alternative treatments.

Current Guidelines and Recommendations

Is it safe to try TRT under current guidelines? It’s important to follow the current recommendations developed by medical experts and organizations.

American Urological Association (AUA) Guidelines

The American Urological Association (AUA) suggests that it’s safe to try TRT for men with clinical symptoms of testosterone deficiency and consistently low testosterone levels.

Before starting TRT, healthcare providers should rule out other causes of low testosterone and discuss the potential benefits and risks with their patients.2

Endocrine Society Guidelines

The Endocrine Society also provides guidance on the safe use of TRT. Their recommendations align with the AUA’s by emphasizing the importance of clinical symptoms and low testosterone levels.

The Endocrine Society encourages healthcare providers to monitor patients closely, particularly during the first year of treatment. They also suggest reevaluating the need for TRT periodically, adjusting the dosage as needed to maintain optimal testosterone levels.3

International Society for Sexual Medicine (ISSM) Guidelines

The International Society for Sexual Medicine (ISSM) focuses on the role of TRT in managing sexual health concerns. According to the ISSM, treatment can be a valuable option for men with low testosterone levels and sexual dysfunction.

However, they emphasize the need for a comprehensive evaluation before initiating treatment. This includes a thorough medical history, physical examination, and laboratory tests.4


Is it Safe to Try TRT at Immortal Male?

At Immortal Male, we follow all guidelines and recommendations to ensure optimal treatment. 

Personalized and Holistic TRT Approach

Immortal Male goes beyond a standard TRT subscription service. We offer a comprehensive lifestyle enhancement tailored to each client. Our experts create customized treatment plans aimed at rejuvenating energy levels, boosting sexual confidence, and improving overall well-being.

Ease of Use and Privacy

Understanding the importance of convenience and privacy, Immortal Male offers an at-home healthcare solution. This makes it easy for clients to access high-quality care. Our services include user-friendly at-home testing kits, discreet delivery options, and readily available online and phone support.

Straightforward and All-Inclusive Pricing

With a focus on transparency, Immortal Male has a clear pricing structure, ensuring no hidden fees or unexpected expenses. A monthly fee of $199 covers all membership benefits, such as doctor consultations, on-demand support, and shipping. Additionally, there is a one-time $99 fee for the at-home test kit, and clients can cancel their membership anytime.

Commitment to Innovation and Research

Immortal Male stays at the forefront of men’s health by offering TRT treatments backed by the latest medical research. We use CLIA-certified medical testing laboratories and concentrate on addressing the unique factors impacting men’s health.

Why is TRT Used?

Journal of Clinical Endocrinology and Metabolism

Stephanie T. Page, John K. Amory, F. DuBois Bowman, Bradley D. Anawalt, Alvin M. Matsumoto, William J. Bremner, J. Lisa Tenover, Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T, The Journal of Clinical Endocrinology & Metabolism, Volume 90, Issue 3, 1 March 2005, Pages 1502–1510,