Unlocking the Truth:
Is TRT Treatment Safe?

Unlocking the Truth: Is TRT Treatment Safe?

Get answers to questions like “what is TRT?” and “is TRT treatment safe?” in this comprehensive article.

Table of Contents


In the realm of testosterone replacement therapy (TRT), determining if TRT is safe can guide you on the path toward personalized care. When considering TRT, you and your healthcare providers embark on a collaborative journey.

Armed with knowledge, you become empowered to take part in the decision-making process. You and your healthcare providers can ensure your safety by:
  • Weighing the evidence
  • Assessing risks
  • Tailoring treatment plans to meet your unique needs 
Is TRT Treatment Safe

Importance of this Partnership

This dynamic partnership ensures that the treatment:
  • Aligns with your preferences
  • Addresses health concerns
  • Strikes a delicate balance between the potential risks and benefits 
In this way, this article will help you address the question: Is TRT treatment safe?

Is TRT Treatment Safe?

So, is TRT treatment safe? The current evidence suggests that TRT is safe when administered under medical supervision. Many studies have examined the safety of TRT and have provided valuable insights.

Cardiovascular Health

Some studies have raised concerns about potential cardiovascular risks associated with TRT.1

But, more recent studies have indicated that managed TRT does not increase the risk of heart attacks or strokes in most men.2

Prostate Cancer

There has been a long-standing concern that TRT might increase the risk of prostate cancer. But, current evidence suggests that TRT does not increase the incidence of prostate cancer in men who are screened before treatment.3
Regular monitoring of PSA levels is crucial to identify any potential issues.

Blood Clotting and Polycythemia

TRT can lead to increased red blood cell production. This is a condition known as polycythemia. While it is a potential side effect, it is manageable through proper dosage change.

TRT may also increase the risk of blood clot formation. Careful monitoring can help mitigate these risks.4

Sleep Apnea

TRT may worsen sleep apnea symptoms in people who already have the condition.5 Testing and checking for sleep apnea before initiating TRT is important.

Other Side Effects

Like any medical treatment, TRT can have various side effects, including:
  • Acne
  • Fluid retention
  • Mood changes
  • Reduced sperm production
These side effects are often mild and can be managed by adjusting the treatment plan. Thus, if you’re wondering “is TRT treatment safe?”, the answer is often “yes.”

Important Note About TRT Safety

The safety of TRT is emphasized by contact with qualified healthcare professionals. Regular follow-up appointments and blood work help ensure the safety of TRT.

Short-Term and Long-Term Risks of TRT

If you’re questioning is TRT treatment safe, you should consider the risks and side effects. Testosterone replacement therapy can have both short-term and long-term risks.
Of course, not everyone experiences these effects. The side effects will vary from person to person. But, here are some known risks and side effects:6

Short-Term Risks and Side Effects

Some of the short-term risks and side effects of TRT include:
  • Fluid Retention: TRT may cause fluid retention. This can lead to bloating or swelling in some people.
  • Skin Conditions: Some people may experience an increase in acne or other skin reactions.
  • Mood Changes: TRT can affect mood and emotions in some people. This can lead to mood swings or increased aggressiveness.
  • Suppressing Testosterone Production: TRT can suppress natural testosterone production in the testes. This can lead to a decrease in sperm production. Decreased sperm production can result in temporary infertility.

Long-Term Risks and Side Effects

Below are some long-term risks and side effects of TRT.

Cardiovascular Events

While the evidence is mixed, there may be an increased risk between TRT and cardiovascular events, such as heart attacks or strokes.

Prostate Cancer

There has been a concern that TRT might stimulate the growth of existing prostate cancer cells. Or it might increase the risk of developing prostate cancer.

Blood Clots

TRT can stimulate the production of red blood cells and increase the risk of blood clots.

Sleep Apnea

TRT may worsen sleep apnea symptoms in people who already have the condition.
Consult with qualified healthcare professionals at Immortal Male. If you’re wondering “is TRT treatment safe?”, you can discuss:
  • Potential risks
  • Benefits
  • Individual considerations before starting TRT

Factors That Influence The Safety of TRT

Is TRT treatment safe and what factors influence its safety? There are many factors that can influence the safety of TRT. Here’s how these factors can influence safety:


The dosage of testosterone administered can impact the safety of TRT. It’s important to start with a smaller dosage and increase it based on individual response and hormone levels. A dosage that is too high can increase the risk of side effects.

Administration Method

There are different administration methods for TRT. The method chosen can affect the safety and effectiveness of treatment.7


Testosterone injections are often administered at regular intervals. This method allows for precise control of dosage. But, it may result in fluctuations in hormone levels between injections.

Gels and Patches

Topical gels or patches deliver testosterone through the skin. They provide a more consistent release of testosterone. But, they may carry a risk of transference to others. Proper application and adherence to safety precautions are necessary.


Testosterone pellets get implanted under the skin. They slowly release the hormone over a period of months. This method provides a steady release of testosterone. But, it requires a minor surgical procedure for insertion.

Individual Patient Characteristics

Individual characteristics can influence the safety of TRT. This can include:
  • Age
  • General health
  • Medical history
  • Specific needs
Pre-existing conditions need careful consideration.

Monitoring and Follow-Up

Regular monitoring is essential to ensure the safety of TRT. This includes checking:
  • Hormone levels
  • Blood counts
  • Other relevant markers 
Regular check-ups help test the treatment’s effectiveness and identify any potential adverse effects.

Importance of Talking to Your Doctor

To make TRT as safe as possible, you need to communicate with your healthcare provider. You should report any changes or concerns as soon as possible, and adhere to the prescribed treatment plan.
The healthcare professionals at Immortal Male are available on-demand to address any concerns.

Potential TRT Risks for Specific Populations

When considering the question “is TRT treatment safe?”, it’s important to be aware of potential risks. Testosterone replacement therapy may have different risks and benefits in specific populations.
Here are some potential considerations:

Older Adults

With TRT, older adults may experience improvements in:
  • Muscle mass
  • Bone density
  • Energy levels
  • Mood
  • Sexual function


Older adults may have a higher risk of pre-existing health concerns. Careful assessment is crucial to reduce potential risks.

Individuals with Existing Health Conditions

Below are some conditions to consider before starting TRT:
  • Cardiovascular Disease: TRT may pose potential risks for people with pre-existing cardiovascular conditions.
  • Sleep Apnea: TRT can worsen sleep apnea symptoms. Evaluation and management of sleep apnea before initiating TRT are important.
  • Diabetes: TRT may have positive effects on glycemic control and insulin sensitivity in people with diabetes. But, close monitoring of blood glucose levels is crucial, as TRT can affect glucose metabolism.

Individuals with a History of Prostate Cancer

TRT may be considered in people with a history of prostate cancer who have undergone successful treatment and have undetectable PSA levels. It may help reduce symptoms of low testosterone and improve quality of life.


There has been historical concern about TRT stimulating the growth of existing prostate cancer cells. It is important to have close monitoring of PSA levels. Regular prostate examinations will help to detect any potential issues.
In all cases, an individualized approach is necessary. Healthcare professionals experienced in TRT can assess the benefits and risks based on an evaluation. They can then tailor the treatment plan to meet your needs and circumstances.

How Healthcare Providers Can Ensure Safety

To determine ”is TRT treatment safe,” healthcare professionals can keep track of people undergoing testosterone replacement therapy.
Below are some common strategies healthcare professionals use to ensure safety.


Before initiating TRT, healthcare professionals conduct a thorough evaluation. This baseline assessment helps establish an understanding of the patient’s health status. It also helps identify any pre-existing conditions or risk factors.

Checking Hormone Levels

Checking hormone levels is crucial to ensure appropriate dosing and treatment response.

Checking Prostate Health

Checking prostate health is important. PSA levels are checked on a regular basis to detect any potential abnormalities.


Regular check-ups on cardiovascular health markers are essential. This includes:
  • Blood pressure
  • Lipid profile (cholesterol levels)
  • Assessments of heart function, such as electrocardiograms (ECGs) or echocardiograms
Regular check-ups of hematocrit and hemoglobin levels help detect any potential clotting. The individual’s experiences and symptom improvements are also taken into consideration.

Follow-Up Visits

Scheduled follow-up visits with healthcare professionals allow for ongoing evaluation. They also help address any concerns that may arise. These visits allow you to communicate your experiences and ask questions.

Concerns About Testosterone Replacement Therapy

There have been concerns and controversies surrounding the safety of testosterone replacement therapy.
The concerns include:
  • Cardiovascular risks 
  • Prostate cancer risk
  • Blood clotting and polycythemia
  • Sleep apnea
To determine is TRT treatment safe, various guidelines and recommendations exist. These guidelines provide evidence-based recommendations for healthcare professionals to follow. Some notable guidelines include:

The Endocrine Society Clinical Practice Guidelines for Testosterone Therapy in Adult Men

These guidelines provide recommendations for the diagnosis and management of testosterone deficiency in adult men.
They cover topics such as:8
  • Screening
  • Monitoring
  • Treatment options
  • Potential risks and benefits

The American Urological Association (AUA) Guidelines on Testosterone Deficiency

The AUA provides guidelines for the evaluation and management of testosterone deficiency in men. The guidelines address various aspects, including:9
  • Diagnosis
  • Treatment options
  • Monitoring
  • Safety considerations

The International Society for Sexual Medicine (ISSM) Guidelines on Male Hypogonadism

These guidelines offer recommendations for the diagnosis and treatment of male hypogonadism.
They provide insights on:10
  • Patient evaluation
  • Treatment options
  • Monitoring protocols

Importance of These Guidelines

Healthcare providers should familiarize themselves with these guidelines and incorporate them into their clinical practice. But, it’s important to note that policies get updated as new research emerges.
Thus, staying informed about the latest research findings in the field is essential for providing safe and effective TRT.

How to Decide if TRT is Right for You

Engaging in shared decision-making between you and your healthcare providers is crucial in determining is TRT treatment safe.
Here’s how you and your healthcare providers can determine if TRT is right for you:

Patient Education

Healthcare providers should provide comprehensive information about TRT, including its:
You should have a clear understanding of the treatment options available and the rationale for TRT.

Assessing Individual Risk Factors

Healthcare providers should conduct a thorough assessment of your medical history to identify any risk factors. This includes evaluating general health and medical conditions that may influence the safety of TRT.

Discussion of Treatment Goals

You and your healthcare providers should discuss the specific goals and expectations of TRT. This may include:
Understanding your priorities helps guide treatment decisions.

Balancing Risks and Benefits

To determine is TRT treatment safe, contact a healthcare provider. Healthcare providers should explain the potential risks and benefits of TRT based on your risk profile. They should discuss the available evidence and provide a balanced perspective.
This can help you make informed decisions. This may involve discussing the uncertainties and limitations of the research as well.

Personal Preferences

Your preferences and values should get discussed and considered in the decision-making process.
You may have personal preferences related to:
  • Treatment duration
  • Administration method
  • Frequency 
Your healthcare providers should discuss these preferences and explore options that align with those preferences.

Discussion of Alternatives

To determine if TRT is right for you, healthcare providers should also discuss alternative treatment options and compare them with TRT.
This may include:
  • Lifestyle modifications
  • Alternative medications
  • Non-pharmacological interventions that may address your symptoms or concerns

Informed Consent

After considering all the relevant information, you should be given time to ask questions and clarify any doubts. You should be encouraged to take part in the decision-making process.

Once you understand the risks, benefits, and alternatives, you can provide informed consent to proceed with TRT.

Shared decision-making requires open and honest communication between you and your healthcare providers. Figuring out is TRT treatment safe is an ongoing process. It often involves many discussions and reassessments as the treatment progresses.
Is TRT Treatment Safe

Find Out “Is TRT Treatment Safe” With Immortal Male

If you’re wondering “is TRT treatment safe?” find out with Immortal Male. Immortal Male is focused on helping you improve your health, longevity, and quality of life with testosterone replacement therapy.
We offer affordable testosterone replacement therapy to help you improve your focus, and strength, and have a more confident sex drive. Get access to convenient, high-quality care in your own home with Immortal Male.

What We Offer

At Immortal Male, we offer:
  • Simple and effective at-home testing
  • Fast and discreet delivery
  • Certified doctors and specialists
  • On-demand access to your healthcare team at no extra cost
Our certified healthcare professionals are there to help support you in your decision to start TRT and manage the potential risks.

Contact Immortal Male Today

Feel energized and more confident with testosterone replacement therapy at Immortal Male. Get started today by reaching out to us at (512) 764-1351 or visiting https://www.immortalmale.com/concierge/.

Journal of Clinical Endocrinology and Metabolism

Stephanie T. Page, John K. Amory, F. DuBois Bowman, Bradley D. Anawalt, Alvin M. Matsumoto, William J. Bremner, J. Lisa Tenover, Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T, The Journal of Clinical Endocrinology & Metabolism, Volume 90, Issue 3, 1 March 2005, Pages 1502–1510, https://doi.org/10.1210/jc.2004-1933B)