When Does
TRT Kick In?

When Does TRT Kick In?

Get answers to questions like “what are the benefits of TRT?” and “when does TRT kick in?”


Table of Contents

Intro to the TRT Timeline

Testosterone replacement therapy (TRT) can help men replenish their natural testosterone levels. But when does TRT kick in? Is there a specific timeline you can start to see the benefits from TRT?

This blog can help answer all your questions about TRT. Immortal Male and our supportive staff can make sure you know everything you need to know about TRT before starting treatment. That way, you can go into TRT treatment with confidence and excitement.
When does TRT kick in?

What is TRT?

TRT is a treatment used to supplement low levels of testosterone in the body. This condition is called hypogonadism. It occurs when the testes are unable to produce enough testosterone.

The treatment works to reverse the effects of hypogonadism. These side effects can include:1
  • Decreased libido
  • Decreased energy levels
  • Lower muscle mass
  • Increased stress
  • Insomnia 
  • Infertility
  • Loss of bone mass and density

Important Note About Prescribing TRT

It’s important to note that TRT is not for everyone. It should be prescribed only after the proper diagnostic tests and follow-up appointments.
The treatment is safe when prescribed and monitored by a qualified medical professional, such as our team at Immortal Male.

What Methods Are Available to Take TRT?

When it comes to TRT, there are a few different methods of delivery to consider. These may also affect the answer to the question “when does TRT kick in?”
Below are some of the most common TRT methods.


TRT injections are an effective way of addressing low testosterone levels in men. These injections work by supplementing the body’s natural supply of testosterone with external sources. 

The testosterone enters the bloodstream and gets distributed throughout the body. This helps to:

  • Increase energy
  • Improve muscle mass
  • Enhance libido
TRT injections are often prescribed for men who are experiencing low testosterone levels due to age, injury, or a medical condition.2

When Does TRT Kick In From Injections?

So, when does TRT kick in from injections? The answer can vary, as everyone’s body reacts differently to treatment. But, most people begin to notice a difference within the first four to six weeks of starting injections.3
Some may experience benefits sooner, while others may take longer to feel the effects. Nevertheless, with continued therapy, testosterone injections can provide long-lasting benefits.


Testosterone patches are another effective and convenient way to regulate hormone levels in the body. These patches work by releasing a low, steady dose of testosterone straight into the bloodstream through the skin.

The patch sticks to the skin and delivers a controlled amount of testosterone over a period of time. This allows the body to absorb the hormone gradually and maintain balance. 

The patches come in different strengths and are applied to clean, dry skin on the:

  • Abdomen
  • Upper arm
  • Thigh
  • Buttocks

When Does TRT Kick In From Patches?

A common question with this method is “when does TRT kick in from patches?” Some men report feeling changes within a week or two, while others may take several weeks or even months to notice a difference.
Testosterone patches are designed to slowly release the hormone into your body over time, so it’s important to be patient and consistent with your treatment.
It’s also worth noting that other factors, such as your health and lifestyle habits, can impact how well the patches work for you. If you have questions or concerns about using testosterone patches, be sure to talk to your healthcare provider.4


These gels work by being absorbed through the skin and into the bloodstream, where they release testosterone over time. 

The idea behind using gels is that they provide a steady stream of testosterone to the body. This can help to balance out natural hormone levels.

But, it’s important to note that testosterone gels may not be suitable for all men, and they can have potential side effects.

When Does TRT Kick In From Gels?

So, when does TRT kick in when using gels? Often, it’s recommended to wait at least two to four weeks before expecting to see any changes. 

But, some people may start experiencing benefits as early as one week after starting their testosterone gel regimen.5

It’s important to remember that consistency is key – make sure you’re applying the gel as directed by your healthcare provider. Don’t give up if you don’t see immediate results. Give your body time to adjust to using the gels.


Testosterone pellets are small, rice-sized pellets that are inserted under the skin, often in the hip or buttocks region. Once inserted, the pellets release testosterone into the bloodstream gradually over the course of several months.6

This ensures a continuous level of testosterone in the body, which can help to improve hypogonadal symptoms.

Testosterone pellets are a convenient and effective treatment option for people seeking to restore their testosterone levels and improve their quality of life.

When Does TRT Kick In From Pellets?

A common question is “when does TRT kick in when using pellets? While every person is different, the general timeline for experiencing the effects of testosterone pellets is typically within 2-4 weeks.
It’s important to note that the full effects of the pellets may not be felt until several months after insertion. But, many men report improved energy, mood, and libido in the early stages of pellet therapy.7
Regardless of which method you and your doctor choose, TRT can be an effective treatment for restoring testosterone levels and improving overall health.

When Does TRT Kick In?: What Are Some Signs that TRT is Starting to Take Effect?

When starting TRT, people may experience various signs and changes indicating that the treatment is starting to take effect. These effects may manifest at different times depending on the person and their response to the treatment.
Below are some common initial signs and changes associated with TRT.8

Increased Energy and Vitality

One of the first noticeable effects of TRT is often an increase in energy levels and vitality. Patients may experience:
  • A boost in motivation
  • Improved mood
  • A general sense of well-being

Improved Libido and Sexual Function

Testosterone plays a crucial role in sexual health. Many patients report an improvement in:
  • Libido
  • Sexual desire
  • Erectile function
Increased interest in sex and improved sexual performance may be observed.

Changes in Body Composition

Testosterone is essential for maintaining lean muscle mass and reducing body fat. With TRT, people may notice changes in body composition. This can include an increase in muscle mass and strength, or a decrease in body fat percentage.

Enhanced Mood and Cognitive Function

Low testosterone levels can impact mood, cognition, and mental well-being. TRT may also help to:
  • Improve mood stability
  • Increase mental clarity
  • Enhance cognitive function
This can include memory and concentration as well.

Improved Physical Performance

Testosterone is known to have an anabolic effect. It contributes to increased muscle strength and endurance. 

People may experience improved physical performance, including:

  • Better athletic performance
  • Increased stamina
  • Faster recovery from exercise

Changes in Skin and Hair

Testosterone influences skin health and hair growth. Some patients may notice improvements in skin tone and texture, as well as increased hair growth and thickness.
Some people may experience changes early on, while others may take longer to notice significant differences. As mentioned above, this also can depend on the method of TRT used. Additionally, not all patients will experience all of these effects, as responses to TRT can be highly individualized.
It’s crucial to work closely with a healthcare professional during TRT to monitor hormone levels, adjust dosage if necessary, and assess the overall response to treatment. Regular follow-up appointments and blood tests will help track progress and ensure optimal outcomes.

Are There Temporary Side Effects Before TRT Fully Kicks in? When Does TRT Kick In?

It is possible for people to experience temporary side effects or fluctuations in hormone levels during the initial phase of TRT before it fully kicks in. These effects can vary among individuals and may subside as the body adjusts to the therapy.
Below are some common temporary side effects or fluctuations that individuals may experience.

Fluctuations in Mood

Some people may experience mood swings, including increased irritability or moodiness, during the early stages of TRT. This can be attributed to the adjustment of hormone levels in the body.

Water Retention

Testosterone can affect fluid balance in the body, leading to temporary water retention or bloating. This can cause patients to experience a sense of increased weight or puffiness.

Acne or Oily Skin

TRT can influence the activity of sebaceous glands, potentially leading to temporary acne breakouts or increased oiliness of the skin. People may be more prone to this if they had an increase in acne as a teenager as well.

Changes in Sleep Patterns

Some patients may experience changes in sleep patterns, including difficulty falling asleep or increased restlessness. This happens as the body adapts to the hormonal changes.

Breast Tenderness or Enlargement

In some cases, TRT can cause temporary breast tenderness or mild breast enlargement, which is called gynecomastia. In most instances, this effect resolves on its own or can be managed by adjusting the treatment protocol.

Fluctuations in Libido

While TRT is generally associated with increased libido, some people may experience temporary fluctuations in sexual desire during the initial phase of treatment. This can be attributed to the adjustment of hormone levels in the body.
It’s important to note that these temporary side effects or fluctuations are often mild and transient. They tend to subside as the body adapts to the treatment and hormone levels stabilize.
If any side effects persist or become bothersome, it is crucial to discuss them with a healthcare professional who can provide guidance and make any necessary adjustments to the treatment protocol.

Realistic Expectations for the Full Benefits of TRT

The timeline for experiencing the full benefits of TRT can vary. Below are some general considerations regarding the timeline and long-term changes associated with TRT.

Short-Term Effects (Weeks to Months)

As mentioned, in the early stages of TRT, people may start to notice initial improvements in energy levels, mood, libido, and sense of well-being. These effects can often get observed within the first few weeks or months of treatment.

Physical Changes (Months to Years)

TRT can lead to changes in body composition. These physical changes often occur over a period of months to years, as the person engages in regular exercise and a healthy lifestyle.

Sexual Function Improvements (Months)

Many individuals experience improvements in sexual function. These improvements may become more apparent within the first few months of TRT.

Cognitive and Mood Improvements (Months)

TRT can have positive effects on cognitive function. Individuals may notice improvements in these areas within a few months of starting treatment. Mood stability and emotional well-being may also improve over time.

Long-Term Changes (Years)

With long-term adherence to TRT and ongoing monitoring by a healthcare professional, patients may experience sustained benefits and long-term improvements for years to come.
It’s essential to maintain a healthy lifestyle, including regular exercise, balanced nutrition, and adequate sleep. These factors can complement the effects of TRT and contribute to a person’s well-being.
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How Immortal Male Can Help

Do you have questions like “when does TRT kick in?” If so, Immortal Male can help. Our team of experts at Immortal Male is dedicated to helping men achieve optimal health and wellness through our tailored testosterone replacement therapy plans.

By providing access to experienced physicians, personalized care plans, and ongoing support, Immortal Male ensures that men can get the testosterone treatment they need in order to live healthier lives.

Lead the Life You Deserve

If you’re looking for comprehensive TRT treatment, reach out to us today. The first step is applying to our membership so we can get a better understanding of what your testosterone needs are.
Then, we will measure your biological markers. Our physician will meet with you to curate treatment. We will share your test results and figure out a plan for your TRT. We will ship your TRT to you in discreet packaging as well.

Reach out to us today for comprehensive and holistic testosterone replacement therapy. We can help you become the man you want to be.

Journal of Clinical Endocrinology and Metabolism

Stephanie T. Page, John K. Amory, F. DuBois Bowman, Bradley D. Anawalt, Alvin M. Matsumoto, William J. Bremner, J. Lisa Tenover, Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T, The Journal of Clinical Endocrinology & Metabolism, Volume 90, Issue 3, 1 March 2005, Pages 1502–1510, https://doi.org/10.1210/jc.2004-1933B)