Can You Gain
Muscle on TRT?

Can You Gain Muscle on TRT?

Get answers to questions like “what are the benefits of TRT?” and “can you gain muscle on TRT?”  

Table of Contents

Introduction to Testosterone Replacement Therapy (TRT)

Testosterone replacement therapy (TRT) is a medical treatment that involves supplementing or replacing testosterone in people who have low levels of this hormone. TRT has many benefits beyond replacing low T levels, though. Some may even wonder – can you gain muscle on TRT?

Testosterone is a vital hormone primarily produced in the testicles in men and in smaller amounts in the ovaries and adrenal glands in women. 

It plays a crucial role in the development and maintenance of various bodily functions, including:1

  • Reproductive health
  • Muscle mass
  • Bone density
  • Mood regulation
  • Cognitive function
  • Libido
Can you gain muscle on TRT?

Who Is TRT Recommended For?

TRT is often recommended for people who have clinically diagnosed low testosterone levels, which is known as hypogonadism. Hypogonadism can be caused by various factors. 

This may include:

  • Aging
  • Certain medical conditions
  • Treatments such as chemotherapy or radiation therapy
The goal of TRT is to restore testosterone levels within the normal range. This helps reduce symptoms and improve well-being.

How Is Testosterone Replacement Therapy Administered?

TRT can be administered through various methods. Below is a detailed look at these methods.


TRT injections work by delivering synthetic testosterone directly into the body through the muscle, restoring testosterone levels to normal. The testosterone then binds to androgen receptors in the body.

TRT injections offer several advantages. These include convenience, stable hormone levels, and the ability to closely monitor dosing. But, it’s important to note that TRT injections should only be administered under the guidance of a qualified healthcare professional.2

Patches or Gels

TRT patches and gels are alternative methods of delivering testosterone. They provide a non-invasive way to administer synthetic testosterone. Here’s an overview of TRT patches and gels:

TRT Patches

Patches are small adhesive patches that contain a specific amount of synthetic testosterone. The patch is applied to clean, dry skin, often on the upper body or back.

The testosterone is absorbed through the skin and enters the bloodstream. Patches are often changed daily or as instructed by the healthcare provider.

TRT Gels

TRT gels are topical formulations that contain synthetic testosterone. The gel is often applied on the upper arms, shoulders, or abdomen. After application, the gel dries quickly, and the testosterone is absorbed through the skin and into the bloodstream.
Gels are often applied once daily as well. The dosage is measured using a predetermined amount or a provided applicator.
If you use gels, it’s important to avoid contact with others, particularly women and children, until the gel is fully absorbed and the application site is covered.3

The Benefits of Gels and Patches

Both TRT patches and gels provide a controlled release of testosterone into the bloodstream over time. They offer convenience and the ability to maintain stable hormone levels.

Buccal Systems

A buccal system is a small device that contains a specific amount of testosterone. The buccal system gets placed against the gum or inner cheek, where it adheres to the mucous membrane. Then, testosterone gets gradually released through the mucous membrane and enters the bloodstream.

The buccal system remains in place for a specified period, often around 12 to 24 hours. After this time, the buccal system gets removed and discarded.
The testosterone from the buccal system is absorbed directly into the bloodstream, bypassing the digestive system and liver metabolism. TRT buccal systems offer a convenient and non-invasive method of testosterone administration.4


Pellets are tiny pills that are implanted under the skin, often in the buttocks. These pellets slowly release a consistent dose of testosterone over the course of several months.

The procedure is quick and virtually painless. Many people report feeling an improvement in their symptoms within weeks.

The choice of treatment method depends on factors such as individual preference, convenience, and the healthcare provider’s recommendations.

Can You Gain Muscle on TRT?

So, can you gain muscle on TRT? Regardless of the method of administration, muscle growth is often an added benefit for hypogonadal men who take TRT.
Testosterone is an important hormone for muscle development. By optimizing testosterone levels, TRT can potentially enhance muscle growth and improve overall body composition.
Here’s how TRT can contribute to muscle gain:5

Increased Protein Synthesis

Testosterone plays a crucial role in protein synthesis. This is the process by which the body builds and repairs muscle tissue.

Adequate testosterone levels support efficient protein synthesis. This leads to enhanced muscle growth and recovery.

Enhanced Muscle Recovery

Testosterone also helps reduce muscle damage and inflammation. This allows for faster recovery after intense workouts.
This can enable you to train more frequently and with higher intensity, which can contribute to muscle growth over time.

Improved Muscle Strength

Testosterone is closely linked to muscle strength. With TRT, patients may experience increased strength, allowing for more productive workouts and the potential to lift heavier weights. This leads to greater muscle stimulation and growth.

Important Note About “Can You Gain Muscle on TRT”

It’s important to note that while TRT can provide a favorable environment for muscle growth, it should get combined with proper resistance training exercises and nutrition to maximize results.
Some essential components of “can you gain muscle on TRT” include:
  • Engaging in regular strength training exercises that target different muscle groups
  • Following a balanced diet with adequate protein intake
  • Ensuring sufficient rest and recovery 

Can You Gain Muscle on TRT?: Differences in Muscle Growth For Those on TRT vs. Those With Naturally High Testosterone Levels

People on TRT can experience muscle gains. But, it’s important to note that there may be some differences compared to people with naturally high testosterone levels. 

Below are a few factors to consider.

Hormone Levels

TRT aims to restore testosterone levels to a normal range. But, it may not replicate the exact hormonal profile of people with naturally high testosterone levels.
Natural testosterone production is regulated by the body’s endocrine system. This ensures the appropriate balance of hormones.
TRT provides exogenous testosterone, which may not perfectly mimic the body’s natural hormonal fluctuations.

Genetic Factors

Genetic factors play a significant role in muscle development. Some people may have a genetic predisposition for higher muscle mass or a better response to testosterone. This is regardless of whether their testosterone levels are naturally high or supplemented through TRT.

Other Hormonal Factors

Testosterone is just one hormone involved in muscle growth. Other hormones such as growth hormone and cortisol also influence muscle development. 

While TRT can optimize testosterone levels, it may not directly impact these other hormones in the same way that naturally high testosterone levels might.

Lifestyle Factors

Muscle gains are influenced by various lifestyle factors. This can include exercise, sleep, and stress management. People with naturally high testosterone levels may also exhibit lifestyle habits that further support muscle growth.

It’s important for people on TRT to adopt a holistic approach by optimizing these lifestyle factors to maximize their muscle gains.

Can You Gain Muscle on TRT?

There may be some differences between people on TRT and those with naturally high testosterone levels. It’s important to recognize that TRT can still provide significant benefits in terms of muscle growth and well-being for men with low testosterone.

TRT can help restore testosterone levels to a normal range, which can support protein synthesis, muscle recovery, and strength gains, as mentioned above.

Can TRT Enhance the Effectsof Resistance Training and Exercise?

By restoring testosterone levels to a normal range through TRT, patients may experience several benefits in conjunction with resistance training. In addition to protein synthesis and muscle strength, TRT can also help with:

Body Composition Changes

TRT can help optimize body composition by promoting a favorable ratio of muscle to fat. With increased muscle mass and strength, and potentially decreased body fat, people may achieve a more toned and defined physique.

Preservation of Lean Mass

In some cases, people with low testosterone may experience muscle loss. TRT can help prevent or slow down this process, preserving lean muscle mass and supporting favorable body composition.
Also, working with a certified personal trainer or exercise specialist can help you increase your muscle gains if that is one of your main goals. They can:
  • Provide personalized guidance on your TRT treatment
  • Design an effective resistance training program
  • Help you make necessary adjustments to your lifestyle and exercise routine to achieve your fitness goals safely and effectively

Other Ways to Aid With “Can You Gain Muscle on TRT?”

While there are no specific guidelines or recommendations exclusively for people on TRT to maximize muscle gains, the general principles of exercise, nutrition, and supplementation for muscle growth still apply.
Below are some key considerations.6


Ensure you follow a balanced diet that supports muscle growth. Consume adequate protein to provide the necessary building blocks for muscle repair and growth. Include a variety of protein sources such as:
  • Lean meats
  • Poultry
  • Fish
  • Eggs
  • Dairy
  • Legumes
  • Plant-based proteins

Caloric Surplus or Deficit

Adjust your calorie intake based on your specific goals. To promote muscle growth, you may need to consume a slight caloric surplus, meaning you consume more calories than your body needs for maintenance.
To promote fat loss while maintaining muscle, a slight caloric deficit may be necessary. Work with a registered dietitian or nutritionist to determine the appropriate caloric intake for your goals.


Ensure you are getting a variety of vitamins and minerals through a well-rounded diet. Adequate intake of nutrients such as vitamin D, calcium, magnesium, and zinc is important for health and optimal muscle function.


Stay well-hydrated to support muscle function, recovery, and health. Aim to drink enough water throughout the day, especially during and after exercise.

Rest and Recovery

Allow your muscles time to recover and grow by incorporating rest days into your training routine. Ensure you get enough sleep to support muscle recovery and hormonal balance.


While a well-balanced diet should provide most of the necessary nutrients, some individuals may consider supplementation. Consult with a healthcare professional to determine if any specific supplements, such as creatine or omega-3 fatty acids, may be appropriate for your individual needs.

Remember that individual responses to exercise, nutrition, and TRT can vary. Make sure you meet with a medical provider before starting TRT.

Are There Any Potential Limitations That May Impact “Can You Gain Muscle on TRT?”

Several factors can influence the extent of muscle gains on TRT. Here are some potential limitations and factors:

Individual Variability

Each person responds differently to TRT and exercise. Factors that can impact the rate and extent of muscle gains include:
  • Genetic factors
  • Age
  • Baseline fitness levels
  • Diet
  • Lifestyle
  • Health
Some people may be more responsive to TRT and experience greater muscle growth, while others may have more modest results.

Dosage and Treatment Protocol

The dosage and treatment of TRT can vary from person to person. Factors such as the initial testosterone levels, treatment method, frequency of administration, and adjustments made during the course of treatment can affect the outcomes.

Treatment Duration

The duration of TRT can also influence “can you gain muscle on TRT?” It takes time for the body to adapt to hormonal changes and for muscle growth to occur.

Consistency with TRT and adherence to an appropriate exercise and nutrition program are crucial for maximizing muscle gains.

Other Health Factors

It’s important to consider other health factors that may impact muscle gains. For example, other factors that can affect muscle gains include:
  • Underlying medical conditions
  • Medications
  • Injuries
  • Hormonal imbalances
  • Lifestyle factors such as smoking or excessive alcohol consumption

Addressing these factors alongside TRT can be important for maximizing muscle gains.

Can You Gain Muscle on TRT? Change Takes Time

It may take time to see noticeable changes, and results depend on a combination of factors.

Remember, muscle gains should be pursued in a safe and sustainable manner. Focus on overall health, consistent adherence to treatment and exercise, and realistic goals to achieve long-term success.

Can you gain muscle on TRT?

Can You Gain Muscle on TRT With Immortal Male?

Immortal Male provides testosterone replacement therapy to men suffering from low testosterone levels. Our clinic offers a range of services that are designed to help men regain their vitality and improve their overall quality of life.
The process of getting TRT with Immortal Male is straightforward and easy. Men can book an appointment online or over the phone. Then, they undergo a comprehensive medical evaluation to determine if they are a good candidate for the therapy.

If approved, our supportive and knowledgeable clinic’s team of doctors will develop a personalized treatment plan that is tailored to their unique needs and preferences. This can help them restore their testosterone levels to healthier and more youthful levels.

Get in Touch With Us Today

If you’re experiencing hypogonadism and think you may want to start TRT, get in touch with us today. Our TRT subscription service can help you every step of the way. 

If you’re looking to gain muscle on TRT, we can also help answer any of your questions.

Journal of Clinical Endocrinology and Metabolism

Stephanie T. Page, John K. Amory, F. DuBois Bowman, Bradley D. Anawalt, Alvin M. Matsumoto, William J. Bremner, J. Lisa Tenover, Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T, The Journal of Clinical Endocrinology & Metabolism, Volume 90, Issue 3, 1 March 2005, Pages 1502–1510,