Diving Into the Potential Downside:
What Are the Cons of Testosterone Injections?

Diving Into the Potential Downside: What Are the Cons of Testosterone Injections?

Are TRT injections suitable for everyone? What are the cons of testosterone injections? Here is a comprehensive guide to help answer your questions.

Table of Contents

What Are the Potential Risks and Side Effects Associated With Testosterone Injections as a Form of Therapy?

Over 4 million men in the US have testosterone deficiency.1 Testosterone injections are used as a form of therapy for men experiencing low testosterone levels. While there are benefits to this treatment, many people also often wonder, what are the cons of testosterone injections? 

These may include, but are not limited to, the following:2
  • Acne
  • Hair loss
  • Mood swings
  • Increased risk of heart disease

However, it is important to note that the risks and side effects of testosterone injections can often be mitigated with proper medical supervision and monitoring. 

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How Do Testosterone Injections Impact Natural Testosterone Production in the Body?

While TRT has proven benefits, it’s crucial to be aware of the potential impact on the body. Here are some key points to consider in terms of natural testosterone levels:

Suppression of Testosterone Production

Testosterone injections can signal the body to decrease its natural production of testosterone. This occurs because the injected testosterone provides the body with sufficient levels. It may lead to a feedback loop that signals the testes to produce less testosterone. 
While this may seem concerning, it is important to note that the purpose of TRT is to replace deficient testosterone levels with an external source to alleviate symptoms and restore overall well-being.

Hormonal Balance and Regulation

By introducing exogenous testosterone, TRT helps restore hormonal balance in individuals.3 It helps address symptoms associated with testosterone deficiency, such as fatigue and low libido. The goal of TRT is to bring testosterone levels within a healthy range to promote vitality.

Controlled and Monitored Dosages

When you receive testosterone injections, the doses are carefully controlled and monitored. Your healthcare provider will assess your T levels and symptoms before determining the dosage. 

Regular check-ups ensure your treatment remains balanced. They do so by combining external testosterone with your body’s natural production.

Personalized Treatment Approach

Everyone responds differently to testosterone injections. Your dosage, frequency, and duration of TRT will be personalized to fit your specific needs and goals. 
Close monitoring of progress and open communication is important. They help make adjustments to optimize the benefits of TRT while minimizing disruptions.

What Are the Cons of Testosterone Injections? Are There Any Long-Term Health Concerns or Risks Associated With Prolonged Use? 

It’s crucial to understand these potential long-term health concerns if you want to use TRT for long-term:

Cardiovascular Health

Many studies suggest a possible association between testosterone use and heart problems.4
While TRT improves blood flow to the heart in men with heart diseases, it’s still important to consult a doctor before starting the treatment, as it can still be dangerous  for some men with heart issues.5
At Immortal Male, we have qualified physicians to help mitigate any risk. They analyze the test reports and lifestyle choices of every client before recommending treatment. Our aim is to provide a tailored solution that can help you achieve long-term wellness.

Prostate Health

Another aspect that raises concerns about TRT injections is their potential impact on prostate health. Testosterone plays a role in prostate growth, which is why there is a concern that TRT could accelerate the growth of prostate cancer cells.6

Liver Function

Testosterone is metabolized by the liver, and prolonged use may put a strain on this organ. However, research has also shown that long-term TRT improves the liver function of hypogonadal men.7

Regular consultations are essential to monitoring any changes in liver enzymes and ensure the overall health of the liver during and throughout treatment. 


Uncontrolled use of testosterone injections can lead to an increase in red blood cell production, which can result in a condition known as polycythemia.8

While this can enhance oxygen-carrying capacity, excessive red blood cell production may increase the risk of blood clots. Regular blood tests and monitoring can help identify and manage this potential side effect.

What Are the Cons of Testosterone Injections? Can Testosterone Injections Lead To Hormonal Imbalances or Disruptions in Other Bodily Functions? 

Some people may wonder if TRT injections could lead to hormonal imbalances in the body. Below are some important points to consider in this regard:

Hormonal Imbalances

In men, low testosterone levels can lead to the following;

  • Decreased sex drive
  • Fatigue
  • Muscle weakness
  • Osteoporosis
Conversely, high testosterone levels can cause aggression and mood swings.

Could TRT Cause Hormonal Imbalances?

When TRT is administered at the right dose, it can result in optimal testosterone levels in the body. On the other hand, inappropriate use or overuse of TRT can cause the hormonal imbalances listed above. It is essential for men to undergo regular check-ups to monitor hormone levels while receiving TRT.  

Testicular Function

Regular use of testosterone injections can also affect your testicular function. External testosterone might signal your testes to produce less testosterone naturally, which could cause them to shrink temporarily.9

But don’t worry; this is usually reversible, and your testicular function will likely return to normal after you stop the injections or adjust the dosage as per your doctor’s recommendation. 


Testosterone injections can temporarily lower sperm production, which may affect fertility. If you plan to have children, talk to your healthcare provider about your concerns before starting TRT. They can adjust your TRT plan to address this issue while still benefiting from testosterone therapy.

Other Body Functions

Testosterone is involved in various body functions, like building muscles, maintaining bone density, and producing red blood cells. Testosterone injections aim to improve these functions when you have low testosterone levels. 

Your healthcare provider will monitor your progress and make adjustments as needed. The aim is to optimize the benefits of TRT while minimizing disruptions to other body functions.

What Are the Psychological or Emotional Side Effects That Individuals May Experience as a Result of Testosterone Injections? 

Like any medical treatment, TRT injections may have psychological effects that individuals may experience, such as: 

  • Increased Sex Drive: Testosterone is responsible for sexual desire and function. Therefore, when T levels are increased through TRT, men often experience an increase in sexual desire. This can be a benefit for individuals who have experienced a decrease in sexual drive.
  • Mood Changes: Sometimes, testosterone injections can make your mood change. You might feel irritated or get angry more easily. However, these effects are usually temporary and can be managed by adjusting your treatment plan.
  • Emotional Sensitivity: Testosterone injections might make you feel more sensitive emotionally. You might experience mood swings. It’s important to talk to your healthcare provider about any emotional concerns.
  • Anxiety and Restlessness: In some cases, testosterone therapy can lead to feelings of anxiety or restlessness. To manage these feelings, make sure to speak to your doctor. 
  • Confidence and Well-Being: Many people feel more confident and have an improved sense of well-being with TRT. You may experience increased energy levels, a better mood, and improved physical performance. These factors can contribute to a positive outlook on life.

Are There Any Complications Specific to Certain Age Groups or Individuals With Pre-Existing Health Conditions? 

When considering TRT injections, it’s essential to understand age-specific risks. Below are some important points to consider in this regard:

Risks for Older Adults

Older adults may have a higher risk of certain complications when using testosterone injections. These include an increased chance of prostate problems or worsening of existing conditions. However, with proper monitoring and guidance, these risks can be mitigated.

Risks for Younger Individuals

In younger individuals, the use of testosterone injections may affect natural hormone production. This can result in a temporary suppression of the body’s ability to produce testosterone naturally. 

Pre-Existing Health Conditions

Individuals with pre-existing health conditions, such as heart disease, liver problems, or certain types of cancer, may require special consideration when using testosterone injections. 

It’s important to have a thorough discussion with healthcare providers. They can assess the risks in relation to health conditions and provide personalized guidance.

Individualized Approach

Healthcare providers take an individualized approach to TRT. When prescribing testosterone injections, they consider age, overall health, and medical history. 
They will carefully assess the potential risks and benefits and closely monitor any complications. The aim is to make adjustments to the treatment plan as needed.

How Do the Cost and Inconvenience of Regular Injections Factor Into the Overall Drawbacks of Testosterone Therapy? 

When considering TRT injections, it’s important to understand the costs involved. Let’s delve into the details:

Financial Considerations

TRT injections can cost different amounts based on dosage, frequency, and duration. While it may involve some financial commitment, the benefits of improved well-being and quality of life can outweigh the costs.

Insurance Coverage

In many cases, testosterone therapy is covered by insurance plans. It’s advisable to check with your insurance provider to understand the coverage details. You should ask about copayments, deductibles, and any limitations or restrictions that may apply.

Inconvenience of Injections

What are the cons of testosterone injections? The regularity of injections can be viewed as an inconvenience by some individuals. 
However, it’s essential to maintain consistency to achieve optimal results. Healthcare providers can guide you on the appropriate injection schedule to minimize any discomfort.


Some individuals may opt for self-administration of injections. This provides flexibility and convenience for patients. Healthcare providers should provide training to ensure safe and effective self-administration.

Alternatives to Injections

TRT Injections are common, but there are other ways to get testosterone, like patches, gels, or pellets. These alternatives might be more convenient if you don’t like injections. 

Are There Any Legal or Ethical Concerns Surrounding the Use of Testosterone Injections?

There has been an increase in the use of testosterone injections in non-medical contexts. This raises concerns about the legality and ethics of their use. Here is what you should know:

Fair Competition in Athletics

In athletics, the use of testosterone injections can raise concerns about fair competition. Some sports organizations have specific rules regarding the use of performance-enhancing substances. It’s important to understand and abide by these regulations to maintain fairness in sports.

Legal Restrictions

Using testosterone injections without a valid medical prescription is against the law in many countries. It’s crucial to obey the rules and regulations surrounding testosterone use to avoid legal trouble.

Misuse and Abuse

Using TRT injections without medical guidance can lead to misuse and potential abuse. This can harm your health. Make sure you use TRT responsibly and with the help of qualified healthcare professionals.

Unregulated Products

Obtaining testosterone from unregulated sources can pose significant risks. These products may be counterfeit and impure, potentially leading to health complications. It’s vital to prioritize safety and only use TRT injections obtained through legal and reputable channels.

Ethical Considerations

Ethical concerns may arise when TRT injections are used without a valid medical prescription. The pursuit of performance gains without a medical necessity can raise ethical questions, as well as health concerns over time. 

Seek guidance from qualified professionals who can assess your individual needs. They can ensure your use of testosterone aligns with medical best practices.
What are the cons of testosterone injections?

How Can Immortal Male Help Individuals Get the TRT They Need?

At Immortal Male, we understand the importance of accessing TRT for those who need it. We offer a range of services and support to help individuals get the TRT they require. Below are some important considerations in this regard:

  • Comprehensive Consultations: Our experienced healthcare professionals provide thorough consultations. They will discuss your symptoms and medical history and conduct necessary tests to determine if TRT suits you.
  • Personalized Treatment Plans: Our experts will create a personalized treatment plan. This customized plan ensures that you receive the optimal dosage and duration of treatment for maximum effectiveness.
  • Convenient Access to Medications: We deliver medications to your home. The discreet packaging ensures easy access and convenience for our clients. Our team will guide you through the process of obtaining your medications safely and efficiently.
  • Ongoing Monitoring and Support: We provide ongoing monitoring and support throughout your TRT journey. Our ongoing concierge service allows us to assess your progress and make any necessary adjustments to your treatment plan.
  • Collaborative Approach: We value open communication and collaboration. Our team works closely with you to address any concerns or questions you may have about TRT. We are here to listen, guide, and support you throughout your journey to optimal hormone balance.

Get in Touch With Immortal Male Today

At Immortal Male, your safety and well-being are our top priorities. We adhere to medical best practices and closely monitor your health to ensure the safe and effective use of TRT. Our healthcare professionals are readily available to address any concerns that may arise. 

If you still have any questions, our team is here to answer them. Sign up for our $199/month membership and start reaping the benefits today.

Journal of Clinical Endocrinology and Metabolism

Stephanie T. Page, John K. Amory, F. DuBois Bowman, Bradley D. Anawalt, Alvin M. Matsumoto, William J. Bremner, J. Lisa Tenover, Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T, The Journal of Clinical Endocrinology & Metabolism, Volume 90, Issue 3, 1 March 2005, Pages 1502–1510, https://doi.org/10.1210/jc.2004-1933B)