What Happens When
You Get Off of TRT?
What Happens When You Get Off of TRT?
Learn about what happens when you get off of TRT and how to ensure a successful transition in this comprehensive article.
Table of Contents
What IsTRT?
Testosterone replacement therapy (TRT) is a medical treatment used to address low levels of testosterone in the body. TRT is effective in increasing muscle mass, bone density, and libido. But what happens when you get off of TRT?

What Is TRT Used For?
TRT can help alleviate symptoms associated with low testosterone, also known as low T, levels in men, also known as hypogonadism. This treatment involves the administration of synthetic testosterone, usually through injections, skin patches, gels, or pellets implanted under the skin.
By administering testosterone, TRT can help restore testosterone levels to a normal range. Research shows that TRT can increase libido, relieve erectile dysfunction, and improve sexual satisfaction.2
What Happens When You Get off of TRT?
Physical Symptoms
Discontinuing TRT can cause a number of physical symptoms, including:3
- Decreased muscle mass
- Decreased bone density
- Decreased libido
- Decreased erectile function
- Decreased bladder wall thickness
- Fatigue
- Weight gain
Emotional Symptoms
- Anxiety
- Depression
- Irritability
- Mood swings
How Long Does It Take for Hormone Levels to Return to Normal After Stopping TRT?
Average Timeframe for Hormone Levels to Regulate
If you are considering stopping TRT, it is important to talk to your healthcare provider about the potential risks and benefits. You and your doctor can work together to develop a plan for tapering off the medication and monitoring your hormone levels.
Long-Term Health Risks Related to Discontinuing TRT
There is limited research on the long-term health risks associated with what happens when you get off of TRT. Nonetheless, as with treatments for many other health conditions, there are still potential risks and side effects when stopping.
Additional Risks
Steps to Ensure a Successful Transition and Maintain Healthy Hormonal Balance
While various physical and emotional side effects are the result of what happens when you get off of TRT, there are ways to reduce their severity.
Several steps can be taken to ensure a successful transition from TRT and maintain a healthy hormonal balance.
- Working with a healthcare provider: A healthcare provider can help manage hormone levels and monitor for any potential complications.
- Gradually reducing TRT dosage: Gradually reducing TRT dosage can help minimize withdrawal symptoms and allow the body to adjust to lower hormone levels.
- Making healthy lifestyle changes: Lifestyle changes like regular exercise and a healthy diet can help support overall health and hormone balance.
- Considering alternative treatments: Alternative treatments, such as natural supplements or hormone replacement therapy, may be an option for managing hormone levels.
Lifestyle Changes to Help Adjust to Lower Hormone Levels
- Regular exercise can help increase testosterone levels naturally.
- A diet rich in fruits, vegetables, lean protein, and healthy fats can help support overall health and hormone balance.
- Stress can impact hormone levels, so finding ways to manage stress, such as meditation or yoga, is important.
- Getting enough sleep can improve overall health and hormone balance.
- Certain supplements like DHEA or zinc may help support hormone balance.
Is It Recommended to Take TRT for Life?
Signs to Avoid Getting Off of TRT
- Long-term TRT can cause greater difficulty adjusting to lower hormone levels.
- Depression or anxiety can cause more severe emotional symptoms after discontinuing TRT.
- Cardiovascular disease can increase the risk of cardiovascular complications after stopping TRT.
- Osteoporosis or low bone density history can increase the risk for bone complications after discontinuing TRT.

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